| Migrasomes A new method of cellular communication |
| Paper ID : 1003-HISTO23 |
| Authors |
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Amany Mohamed Hosney Elshawarby * Faculty of Medicine
Ain Shams University |
| Abstract |
| Migrasome is a novel vesicular structure discovered in migrating cells. During cell migration, projections named retraction fibers” are pulled from the rear end of cells, and large vesicular structures the pomegranate-like structures (PLS named “migrasomes”) grow on the retraction fibers. When the cell migrates away, the retraction fibers break, and migrasomes are left behind. The released PLSs can be directly taken up by the surrounding cells. The process of releasing migrasomes into the extracellular space is named as “migracytosis”. The number of smaller vesicles in migrasomes varies greatly; some migrasomes contain up to 300 vesicles, while most contain fewer than 10. Migrasomes contain many small vesicles, mRNA, miRNA, Tetraspanin 4(TSPAN4 protein), integrin and cholesterol and the damaged mitochondria Observation under the transmission electron microscope has remained the most reliable and definitive method for identifying a migrasome. TSPAN4 is used as a marker of migrasomes The role of migrasomes in health and diseases 1-In embryonic development, the signal molecules are packaged in the migrasomes and released to the designated location to activate the surrounding cells. Migrasomes can be phagocytosed by surrounding cells to achieve material transport and information transmission between cells 2-Migrasomes are used as carriers of damaged mitochondria (mitocytosis) .3-Viruses can spread by inducing the formation of migratory bodies to promote cell migration. 4-Migrasomes are related to the immune escape and metastasis of cancer. 6-Migrasomes can act as disease indicators |
| Keywords |
| Migrasomes- migracytosis- mitocytosis |
| Status: Abstract Accepted (Oral Presentation) |